Volume 9, Issue 1

Petiveria alliaceae EXTRACT HAD A PROTECTIVE IMPACT ON OXIDATIVE STRESS BIOMARKERS IN MALE RATS WITH LIPOPOLYSACCHARIDE-INDUCED ENDOTOXICITY

Olabisi Ogunrinola1, Omolade Fajana2, Rahmon Kanmodi3, Oluwaseyi Ogunrinola4, Aderemi Adeyemi5, Oluwatosin Adu6, Olugbenga Oladimeji7, and Babajide Elemo8
1Lagos State University, Ojo, Nigeria, 2Lagos State University, Ojo, Nigeria, 3Lagos State University, Ojo, Nigeria, 4Lagos State University, Ojo, Nigeria, 5Lagos State University, Ojo, Nigeria, 6Lagos State University, Ojo, Nigeria, 7Lagos State University, Ojo, Nigeria, and 8Lagos State University, Ojo, Nigeria
DOI:10.36108/jrrslasu/2202.90.0130

Abstract


Introduction: An imbalance between free radicals and antioxidants causes oxidative stress, which has detrimental consequences for a variety of health issues. Petiveria alliaceae (P. alliaceae) is a global plant having a variety of bioactive chemicals that have a variety of therapeutic uses. Aims: The objective of this study was to investigate the protective effect of P. alliaceae leaf aqueous extract on oxidative stress biomarkers in male rats with lipopolysaccharide (LPS) induced-endotoxicity. Materials and Methods: Twenty-five (25) male albino rats were divided into five (n = 5) groups at random. Group 1 was used as a control, Group 2 was given P. alliaceae aqueous extract (1000 mg/kg body weight), Group 3 was given LPS, a single intraperitoneal dose (4 ml/kg body weight), and was observed for 4 hours before being sacrificed, Group 4 was given LPS (observed for 4 hours) and treated with P. alliaceae for 7 days, Group 5 was given P. alliaceae extract for 7 days, then Spectrophotometric analysis was used to evaluate the activities of oxidative stress biomarkers (catalase (CAT) and superoxide dismutase (SOD) in plasma, erythrocytes, brain, liver, kidney, and heart. Results: As seen in this work, oxidative stress is a characteristic of LPS-induced endotoxicity. Following LPS injection, P. alliaceae leaf aqueous extract significantly (p 0.05) increased CAT and SOD activities. Conclusion The aqueous extract of P. alliaceae leaf reduced the effect of endotoxins in the body by mopping up free radicals, according to the findings


Keywords: Petiveria alliaceae, Lipopolysaccharide, and Oxidative stress markers

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